My dog's issues started with flea bites. He developed a bacterial/yeast problem from that which lead to oral antibiotics and antifungals. He never had any GI issues, just skin problems. It seems like it was a downward spiral from the flea incident. I went to two vets, a dermatologist, and a holistic vet. They all gave me new products and supplements to try, as well as immunotherapy drops. I tried an elimination diet, different cleaning methods, air filters, homemade food, raw food, etc. You name it, I have tried it. I limited Enzo's time outdoors, thinking it must be the mold allergy (we live on the coast). I have done dermal allergy testing, the blood test, saliva test, genetic test, etc., to get answers. The last time I saw the holistic vet, she said that Enzo may be the 4th dog in her 18 year practice that she was unable to help. The dermatologist recommended that horrible hydrolized food (ingredients are truly awful), and Apoquel, which I refused. I went to her to find the source of the problem, not mask it with immune-suppressing drugs. I had suggestions from two of the vets that lead to a worsening of the problem, so Enzo went on more antibiotics and antifungals. Once I tried Yeast Beasty Animaleo oil on a hotspot on his lower jaw that was red and crusty, which made the problem explode, necessitating another round of antibiotics and antifungals. Enzo has been on the same diet for a year now since everything seemed to make him flare...from other proteins to grains. I have been grasping at straws. The most recent test I did was the Gut Biome test since "leaky gut" (which the dermatologist denied existed) seemed to be a potential cause of my dogs skin issues. I had been giving my dog Fido's Flora probiotics, which I figured had replaced the good bacteria in his colon...wrong! There was several deficiencies and some overgrowth (due to not having the right bacteria to crowd out the bad). The suggestion was to use fecal transplant. I hesitated. I asked the holistic vet about it, and she agreed. So, I started giving Enzo the pills. He received about half of the pills prior to my vacation. I took Enzo to the kennel, and gave them a long list of instructions and a bag of supplements and skin products. I texted them several times, and they said the hotspots were healing. I assumed it was BS and they didn't want me to worry. He's stayed there several times. When we came home, his coat was thick, the 6 hotspots that he had were completely gone, I mean COMPLETELY. One of the hotspots has been there since last September! I could control it with MiconaHex shampoo, Duoxo calm allergy spray, and MiconaHex mousse or wipes, but nothing ever completely resolved, until now. My husband and I were both in shock. He use to tease me about how many hours a week I spent on Enzo, either making food, researching treatments, or researching products. I am happy but miffed. I have stressed about Enzo for the last 1 1/2 years, feeling that I was letting him down. I am mad that NOT ONE of the vets recommended this test. In all fairness to the holistic vet, we have only seen her twice. I have spent thousands on finding the answer, and was told to give up and just treat the symptoms, because his condition could only be controlled, not cured. Enzo is also much happier. He wakes up with a big smile and prances around the house. I just hope this keeps up, but I am so shocked by the turnaround in his skin, that I had to write a review, in the hopes of helping others out there.